Cronkhite-Canada syndrome in an adult with titanium orthopaedic implants

Cronkhite-Canada syndrome (CCS) is a peculiar nonhereditary, gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities, including skin hyperpigmentation, alopecia and onychodystrophy. It has high mortality rate of about 50% to 60% . When the patient appeared at the dermatology department, we should pay attention to multisystem manifestations to make the right diagnosis. We herein report an adult with CCS improved after removing titanium implants.