Translational strategies in drug development for knee osteoarthritis.

Drug Discovery Today(2020)

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摘要
•Osteoarthritis (OA) patients are in need of new, disease-modifying drugs.•Disease-modifying OA drugs could target cartilage repair or degradation pathways.•Development of intra-articular OA drugs is associated with unique challenges.•OA drug candidate dosing strategy is defined regardless of administration route.
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