Discovering Essential Multiple Gene Effects Through Large Scale Optimization: An Application to Human Cancer Metabolism

IEEE/ACM Transactions on Computational Biology and Bioinformatics(2021)

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摘要
Computational modelling of metabolic processes has proven to be a useful approach to formulate our knowledge and improve our understanding of core biochemical systems that are crucial to maintaining cellular functions. Towards understanding the broader role of metabolism on cellular decision-making in health and disease conditions, it is important to integrate the study of metabolism with other co...
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关键词
Biochemistry,Gene expression,Biological system modeling,Cancer,Computational modeling,Biomass,Perturbation methods
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