IL-33 induced airways inflammation is partially dependent on IL-9.
Cellular Immunology(2020)
摘要
•IL-33 induced airways hyperresponsiveness, inflammation, and goblet cell hyperplasia are attenuated in IL-9 deficient mice.•IL-9 is required for IL-33 induced remodelling in asthma.•IL-9 is one downstream cytokine of IL-33 in asthmatic airways.
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关键词
IL,WT,AHR,ILC2s,DCs,NK,BALF,Mch,NS,H&E,PAS,α-SMA,PBS,TNF-α,IFN-γ,TSLP
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