SH2B1 protects cardiomyocytes from ischemia/reperfusion injury via the activation of the PI3K/AKT pathway

Guo Xin,Li Xu-yong,Hu Shan,Wu Gang,Chen Zhen,Liu Ji-Jun,Ye Ping,Chen Man-hua

International Immunopharmacology（2020）

引用 22|浏览7

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摘要

•SH2B1 overexpression protects cardiomyocytes from ischemia/reperfusion injury.•SH2B1 overexpression alleviates MIRI-induced inflammation, apoptosis and ROS.•SH2B1 activates pro-survival PI3K/AKT pathways to repress myocardial inflammation, apoptosis and ROS under MIRI.

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关键词

SH2B1,Hypoxia/reoxygenation,Ischemia/reperfusion,PI3K,AKT

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