Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.

EUROSURVEILLANCE(2020)

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摘要
The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
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关键词
COVID-19,SARS-CoV-2,antibodies,coronavirus,humoral immunity,immunofluorescence assay,microneutralisation test,western blotting,whole-genome sequencing
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