Continued benefit demonstrated with BAY 81-8973 prophylaxis in previously treated children with severe haemophilia A: Interim analysis from the LEOPOLD Kids extension study.

Gili Kenet,Rolf Ljung,Luminita Rusen,Bryce A Kerlin,Victor Blanchette,Sonata Saulytė Trakymienė,Valentina Uscatescu, Horst Beckmann,Despina Tseneklidou-Stoeter,Nikki Church

Thrombosis Research（2020）

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摘要

•In haemophilia, prophylactic FVIII replacement is the standard of care Char = 77•BAY 81-8973 is an unmodified, full-length recombinant human factor VIII Char = 71•The LEOPOLD Kids extension has shown excellent outcomes in paediatric patients Char = 83•BAY 81-8973 was efficacious and well tolerated for >4.5 years for prevention and treatment of bleeds Char = 85

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ABR,AE,BU,ED,EHL,PTP,Q,rAHF-PFM,rFVIII,rFVIII-FS,SHL

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