Hypobaric hypoxia induced fear and extinction memory impairment and effect of Ginkgo biloba in its amelioration: Behavioral, neurochemical and molecular correlates.

•Hypobaric hypoxia (HH) causes anxiogenic behavior and fear extinction deficit.•HH exposure alters corticosterone, glutamate and GABA levels in limbic region.•HH elicits pyknosis, decreases synaptic plasticity and synaptic protein expression.•Ginkgo biloba extract (GBE) administration ameliorates HH caused extinction deficit.•GBE restores altered neurotransmitter levels and synaptic function in limbic region.