Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.

Emmanuel Salomon,Marjorie Schmitt,Elisabeth Mouray,Alastair G McEwen,Lotfi Bounaadja,Morgan Torchy,Pierre Poussin-Courmontagne,Sarah Alavi,Céline Tarnus,Jean Cavarelli,Isabelle Florent,Sébastien Albrecht

Bioorganic Chemistry（2020）

引用 11|浏览24

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摘要

•Antiplasmodial activity of racemic aminobenzosuberone derivatives.•Crystal structure analysis of protein - ligand complexes.•ADME-Tox and pharmacokinetic studies.

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关键词

PfA-M1 aminopeptidase,Aminobenzosuberone inhibitors,Protein crystallization,Antiplasmodial activity,ADMET studies

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