Medi3726, A Prostate-Specific Membrane Antigen (Psma)-Targeted Antibody-Drug Conjugate (Adc) In Mcrpc After Failure Of Abiraterone Or Enzalutamide

Johann S. De Bono,Mark T. Fleming,Judy Sing-Zan Wang,Richard Cathomas,Marna Williams,John G. Bothos,Kemal Balic,Song Hye Cho,Pablo Martinez,Daniel Peter Petrylak

JOURNAL OF CLINICAL ONCOLOGY（2020）

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摘要

99Background: MEDI3726 is an ADC targeting PSMA. Once bound to PSMA and internalized, the released pyrrolobenzodiazepine dimer toxin crosslinks DNA and triggers cell death. This phase 1 study evalu...

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