Hypomethylation of DNA promoter upregulates ADAMTS7 and contributes to HTR-8/SVneo and JEG-3 cells abnormalities in pre-eclampsia

Lu Zhang,Fei Zhao,Chuan Li,Hong Li,Qian Tang,Yunqing Chen,Yushuang Yao,Zhaoxia Ding,Yinglei Xu,Aiping Chen,Shiguo Liu

Placenta（2020）

引用 6|浏览8

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摘要

•The expression of ADAMTS7 is increased in PE placentas.•Hypomethylation of ADAMTS7 promoter increases gene transcription.•ADAMTS7 inhibits cell viability, migration, and invasion of HTR-8/SVneo and JEG-3 cells in vitro.

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关键词

Pre-eclampsia,ADAMTS7,DNA methylation,Trophoblast cells

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