Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: A meta-analysis

•This meta-analysis compared PAC and PAM for H. pylori infection.•Eighteen high quality RCTs involving 3264 patients were included for the final analysis.•In general, both PAC and PAM regimens were effective and comparable in eradicating H. pylori.•The PAM showed greater efficacy than the PAC in recent years, especially for people over 60 years old.