The road ahead for health and lifespan interventions

•Translation of the advances made from model organisms to human clinical trials still remains a challenge, due to the high heterogeneity in the responses to the different anti-aging interventions (drugs, exercise, diet). How these interventions increase lifespan and improve healthspan in humans by targeting the hallmarks of aging is still unknown.•Successful assessment in the efficacy of an intervention that delays aging will require validation through stringent outcome measures of phenotypic enhancement of longevity in various biological systems.•Using ClinicalTrials.gov, a database of privately and publicly funded clinical studies conducted around the world, we found that exercise, fasting and CR are the interventions with the highest number of clinical trials that target aging as a condition followed by the compounds resveratrol metformin and NAD precursors.