Fatty Acids regulate the biology of cholangiocarcinoma cells

Introduction: The incidence of cholangiocarcinoma (CCA) is increasing worldwide and is associated with poor patient outcomes. Identification molecular features of CCA could be helpful in designing new therapeutic approaches. Cancer cells are often exposed to a metabolically challenging environment with scarce availability of nutrients. This metabolic stress leads to changes in the balance between endogenous synthesis and exogenous uptake of fatty acids (FAs), which are needed by cells to support their own growth. Moreover, alterations in lipid metabolism may affect the response of tumor cells to different drugs. Yet, little is known about the lipid profile of CCA.