Rebound after discontinuation of teriflunomide in patients with multiple sclerosis: 2 case reports

•Teriflunomide is an oral first-line therapy used in relapsing forms of MS.•The washout period of teriflunomide may be accelerated by cholestyramine.•Clearance of teriflunomide (<0.02 µg/ml) are usually verified after washout period.•Cases of MS relapse has been reported after the withdrawal of first-line therapies.•Drug switching is possible after cholestyramine washout without level verification.