Talapro-2: A Placebo-Controlled Phase Iii Study Of Talazoparib (Tala) Plus Enzalutamide (Enza) For Patients With First-Line Metastatic Castration-Resistant Prostate Cancer (Mcrpc)

Neeraj Agarwal,Neal D. Shore,Curtis Dunshee,Lawrence Ivan Karsh,Arun Azad,Andre P. Fay,Joan Carles,Beth Sullivan,Nicola Di Santo,Mohamed Elmeliegy,Xun Lin,Ruben G. W. Quek,Akos Czibere,Karim Fizazi

JOURNAL OF CLINICAL ONCOLOGY（2020）

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摘要

TPS264Background: TALA is a poly(ADP-ribose) polymerase (PARP) inhibitor that inhibits PARP1/2 and traps PARP on DNA, preventing DNA damage repair (DDR) and causing death of cells with DDR mutation...

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