Impressive clinical response to anti-PD-1 therapy in epithelioid mesothelioma with high clonal PD-L1 expression and EML4-ALK rearrangement

Giuseppe Bronte,Angelo Delmonte,Marco Angelo Burgio,Alberto Verlicchi,Maurizio Puccetti,Sara Bravaccini,Paola Cravero,Maria Maddalena Tumedei,Danila Diano,Giulio Rossi,Paola Ulivi,Giovanni Martinelli,Lucio Crinò

Lung Cancer（2020）

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摘要

•Various clinical trials are investigating immune checkpoint inhibitors in mesothelioma patients.•We report a mesothelioma patient with 100 % PDL1 expression in brain metastasis.•The patient was treated with pembrolizumab, achieving impressive clinical response.

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关键词

MPM,OS,PD-L1,CTLA-4,18FDG-PET/CT,MRI,IHC,FISH,NGS,ALK,EML4,MET

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