A multifunctional MOF-based nanohybrid as injectable implant platform for drug synergistic oral cancer therapy

•The hybrid material integrating MOFs into hydrogels are designed for the first time.•Doxorubicin and celecoxib are coloaded in the system for local oral cancer therapy.•The nanocomposite realizes simultaneously pH-responsive dual drug sustained release.•The nanocomposite enhances the antitumor effect and mitigates toxic side-effects.•Original data of MOFs reveals no permanent toxic effect, only reversible anomalies.