The taming of PARP1 and its impact on NAD+ metabolism

Sarah Hurtado-Bagès,Gunnar Knobloch,Andreas G. Ladurner,Marcus Buschbeck

Molecular Metabolism（2020）

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摘要

•Beyond DNA repair, PARP1 is essential for metabolic homeostasis.•Epigenetic mechanisms prevent metabolic disorders through PARP1 taming.•Beyond cancer, the development of PARP1 inhibitors offers diverse clinical potential.

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关键词

PARP1,NAD+,Epigenetics,MacroH2A,Metabolism,Homeostasis

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