The impact of completion of chemotherapy on the efficacy of irinotecan in the preoperative chemoradiotherapy of locally advanced rectal cancer: An expanded analysis of the CinClare phase III trial
Clinical colorectal cancer, 2020.
Dose-effect relationshipIrinotecan competitionNeoadjuvant chemoradiotherapyRectal cancerpCR
Our analysis suggested higher completion of concurrent irinotecan was associated with better tumor response for patients with locally advanced rectal cancer with UGT1A1∗1∗1 or UGT1A1∗1∗28 phenotypes in the neoadjuvant setting, and at least 4 cycles was recommended.
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