The impact of completion of chemotherapy on the efficacy of irinotecan in the preoperative chemoradiotherapy of locally advanced rectal cancer: An expanded analysis of the CinClare phase III trial

Jingwen Wang
Jingwen Wang
Chao Li
Chao Li
Lifeng Yang
Lifeng Yang

Clinical colorectal cancer, 2020.

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Keywords:
Dose-effect relationshipIrinotecan competitionNeoadjuvant chemoradiotherapyRectal cancerpCR

Abstract:

Our analysis suggested higher completion of concurrent irinotecan was associated with better tumor response for patients with locally advanced rectal cancer with UGT1A1∗1∗1 or UGT1A1∗1∗28 phenotypes in the neoadjuvant setting, and at least 4 cycles was recommended.

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