FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy.

•Levels of NAMPT expression were increased in a sepsis-related ALI mice model.•NAMPT inhibitor FK866 attenuated sepsis-induced ALI by upregulating autophagy.•JNK was a potent negative regulator of autophagy conferred by FK866 on lung protection.