Osteopontin-loaded PLGA nanoparticles enhance the intestinal mucosal barrier and alleviate inflammation via the NF-κB signaling pathway.

Feng Wei,Yuhuang Lang,Qiang Shen,Lin Xu,Nuo Cheng,Yan Chu,Hongwei Lyu,Fengyuan Chen

Colloids and Surfaces B: Biointerfaces（2020）

引用 17|浏览6

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摘要

•Hyaluronic acid (HA)-functionalized osteopontin (OPN)-loaded PLGA nanoparticles were fabricated.•BSA/OPN-NPs have good morphology, size, zeta potential, dispersion and biocompatibility.•Surface HA functionalization of NPs targets colitis cells for drug delivery.•BSA/OPN-NPs enhanced the intestinal barrier and alleviated inflammation.•BSA/OPN-NPs alleviated inflammatory bowel disease through the NFκB signaling pathway.

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关键词

Osteopontin,Polymeric nanoparticle,Targeted drug delivery,Inflammatory bowel disease,Intestinal barrier

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