Ibrutinib Suppresses Intracellular Mycobacterium Tuberculosis Growth by Inducing Macrophage Autophagy.

•Ibrutinib reduces intracellular Mtb survival in human macrophages.•Ibrutinib induces complete autophagy flux targeting intracellular Mtb.•Ibrutinib induces autophagy through inhibition of BTK/Akt/mTOR pathway.•Ibrutinib reduces Mtb load in mediastinal node and spleen of Mtb infected mice.•Ibrutinib is a potential host-directed therapy candidate against TB.