Protein kinase Cα promotes proliferation and migration of schwann cells by activating ERK signaling pathway.

Jiannan Li,Zhan Zhang,Jiangbo Wang,Shuang Du,Dengbing Yao,Rangjuan Cao,Shusen Cui

Neuroscience（2020）

引用 7|浏览16

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摘要

•PKCα is upregulated in Schwann cells of distal nerve stumps as long as 28 days in rat sciatic nerve transection model.•PKCα promotes Schwann cell proliferation and migration in SCs.•PKCα promotes proliferation and migration via ERK pathway.

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关键词

Bax,Bcl-2,bFGF,DMSO,EdU,ERK,FASLG,GAPDH,IL-6,LIF,MCP-1,NC,NF2,NT3,P2,PD,PKCα,PMA,PNI,PNS,RT-qPCR,SAPK/JNK,SC,SPP1,TGF-β1,TLR4,TNFα,WD

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