Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic-pharmacodynamic modelling from in vitro data.

Chenyan Zhao,Pikkei Wistrand-Yuen,Pernilla Lagerbäck,Thomas Tängdén,Elisabet I Nielsen,Lena E Friberg

International Journal of Antimicrobial Agents（2020）

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摘要

•Minocycline and polymyxin B in combination showed net killing of a multidrug-resistant Klebsiella pneumoniae isolate.•Bacterial killing and drug interaction were successfully quantified in a pharmacokinetic/pharmacodynamic (PKPD) model.•The minocycline effect was enhanced by polymyxin B, but not vice versa.•A clinical benefit of the combination was suggested also when human PK was considered.

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关键词

Polymyxin B,Minocycline,Combination therapy,Pharmacokinetic/pharmacodynamic model,In vitro time–kill study,Multidrug-resistant Klebsiella pneumoniae

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