Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer's disease.

Xian-Feng Huang, Yan-Hua Dong,Jin-Hui Wang,Heng-Ming Ke,Guo-Qiang Song,De-Feng Xu

Bioorganic & Medicinal Chemistry Letters（2020）

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摘要

•A novel series of rutaecarpine-based pde5inhibitors were synthesized.•Compound 8i exhibited PDE5 inhibition with IC50 values about 0.087 μM.•Compound 8i showed significant effects against scopolamine-induced cognitive impairment in vivo.

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关键词

PDE5 inhibitors,Rutaecarpine,Alzheimer’s disease

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