Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction.

Objective: The aim of this study was to investigate the predictive value of copeptin levels in the development of contrast-induced nephropathy (CIN). Methods: A total of 274 patients diagnosed with ST-elevation myocardial infarction (STEMI) and who had undergone primary percutaneous coronary intervention were included in the study. The patients were divided into two groups according to the presence (CIN+) or absence (CIN-) of CIN. These groups were compared in terms of demographic characteristics, laboratory findings and risk factors. Results: Copeptin levels (10.68 +/- 6.43 vs. 7.07 +/- 05.53 pmol/l; p<0.001) and peak creatinine (1.46 +/- 1.20 vs. 1.03 +/- 0.20 mg/ dl; p=0.005) were significantly higher in the CIN+ group than in the CIN- group. Female gender was significantly more prevalent in the CIN- group compared to the CIN+ group (19% vs. 8.6%; p<0.05). Copeptin level at hospital admission (OR: 2.36, p=0.005) was found to be an independent predictor for CIN development. Conclusion: Copeptin level is an independent predictor of CIN development in patients with acute STEMI that can be detected rapidly and easily. This result indicates that physicians should be aware of the possibility of CIN development in patients with high copeptin levels and preventive measures should start early. (C) 2020 Sociedade Portuguese de Cardiologia. Published by Elsevier Espana, S.L.U.