Quantification of immuno-regulatory cytokine and toll-like receptors gene expression in dogs with generalized demodicosis.

Sandeep P Soman,Shanker K Singh,Priyambada Kumari,Soumen Choudhury,Alok Singh,Sarita Kanwal, Richa Khushboo,Satish K Garg

Veterinary Parasitology（2020）

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摘要

•Overexpression of TLR2 is accountable to the clinical signs of demodicosis.•Demodex induces systemic TGF-β and IL-10 overexpression to escape the host immunity.•Reduced TLR6 expression could be helping Demodex mites to proliferate.•TGF-β and IL-10 gene remains unaltered in the skin lesions of dogs with GD.

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关键词

Demodex,Interleukin-10,Interferon-γ,Transforming growth factor-β,Toll-like receptor

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