Construction of redox-responsive tumor targeted cisplatin nano-delivery system for effective cancer chemotherapy.

The nano-delivery system HA-(BPEI-SS-Pt)-1/4 for cisplatin has been developed for effective cancer chemotherapy. HA-(BPEI-SS-Pt)-1/4 showed specific tumor-targeting ability, redox-responsive drug release manner, and more effective antitumor performance along with minor side effects and systemic toxicity compared with cisplatin, which is of great significance for the chemotherapeutic drug in clinic.