Self-assembled peptide dendrigraft supraparticles with potential application in pH/enzyme-triggered multistage drug release.

•Ionic crosslinking of biodegradable peptide dendrimers can lead to well-defined polymeric supraparticles.•pH-sensitive size-switchable dendrimer-based supraparticles show a remarkable capacity to encapsulate different molecules.•After pH-triggered disassembly, the cargo trapped in dendrimers can be released by action of trypsin enzyme.•Dendrimer supraparticles are promising multistage nanocarriers with remarkable properties for drug delivery applications.