Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis.

Zhuo Huang,Fan Guo,Zijing Xia,Yan Liang,Song Lei,Zhouke Tan,Liang Ma,Ping Fu

Biomedicine & Pharmacotherapy（2020）

引用 31|浏览9

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摘要

•The GPR120 expression is downregulated in the kidneys of cisplatin-induced AKI.•TUG891, a synthetic GPR120 agonist, protected against cisplatin-induced AKI.•Activation of GPR120 by TUG891 inhibited ER stress and apoptosis in cisplatin injured kidneys.

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关键词

Cisplatin,Acute kidney injury,GPR120,Endoplasmic reticulum stress,Apoptosis

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