Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein.
Bioorganic & Medicinal Chemistry(2020)
摘要
•Rational modifications on a zinc-ejecting anti-RSV scaffold.•Synthesis of novel analogues to explore antiviral SARs.•New inhibitors of RSV replication identified.•Molecular dynamics and molecular docking studies on the RSV M2-1 protein.
更多查看译文
关键词
Molecular Modelling,RSV,Small-molecules,Zinc-ejecting compounds,Molecular dynamics
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络