Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1+T cells

Wang Zhuoya,Zhao Nannan,Zhang Aiping,Wang Guoyan,Dong Menghua,Zhang Jiashen,Xiong Yanlian,Luan Xiying

Cellular Immunology（2020）

引用 7|浏览32

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摘要

•hPMSCs alleviate the inflammation of GVHD mice.•hPMSCs reduce the generation of PD-1 + T cells in GVHD mice.•hPMSCs decrease the expression of PD-1 on T cells by increasing GSH and GST level.

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关键词

Graft-versus-host disease (GVHD),Mesenchymal stromal cells (MSCs),Programmed death-1 (PD-1),Reactive oxygen species (ROS),Glutathione (GSH),Glutathione S transferase (GST)

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