Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides.
Molecular Cell(2020)
摘要
While gapmers efficiently knock down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al. (2020) also demonstrate that Pol II termination is not observed with gapmers targeting the 3' terminal portions of the transcript.
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