Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates.

Vincent Madelain,Aurélie Duthey,France Mentré,Frédéric Jacquot,Caroline Solas,Bruno Lacarelle,Audrey Vallvé,Stéphane Barron,Laura Barrot, Stéphanie Munweiler,Damien Thomas,Caroline Carbonnelle,Hervé Raoul,Xavier de Lamballerie,JérémieGuedj

Antiviral Research（2020）

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摘要

•We aimed to evaluate ribavirin addition to favipiravir in Ebola virus infected NHP.•Ribavirin combination provided no gain survival compared to favipiravir monotherapy.•Strong association between ribavirin concentration and hemoglobin drop was observed.

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关键词

Ebola virus disease,Favipiravir,Ribavirin,Non-human primates,Viral kinetics

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