Engineering light-controllable CAR T cells for cancer immunotherapy

Ziliang Huang
Ziliang Huang
Yiqian Wu
Yiqian Wu
Molly E Allen
Molly E Allen
Yijia Pan
Yijia Pan
Phillip Kyriakakis
Phillip Kyriakakis
Ya-Ju Chang
Ya-Ju Chang

Science advances, 2020.

Cited by: 0|Bibtex|Views65|Links
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Abstract:

T cells engineered to express chimeric antigen receptors (CARs) can recognize and engage with target cancer cells with redirected specificity for cancer immunotherapy. However, there is a lack of ideal CARs for solid tumor antigens, which may lead to severe adverse effects. Here, we developed a light-inducible nuclear translocation and di...More

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