Longitudinal Retinal Layer Changes and Clinical Outcome in Patients with Multiple Evanescent White Dot Syndrome

Purpose: To evaluate longitudinal changes in retinal layer thickness and clinical outcome in patients with MEWDS. Methods: In 20 patients with MEWDS, SD-OCT images and BCVA were assessed at baseline, and at months 1, 3, and 12. SD-OCTs were segmented and measurements were performed within the fovea and a MEWDS lesion. Baseline and follow-up values in the affected eye were compared to measurements performed at the corresponding location in the fellow eye. Results: ONL thickness was 4.7% thicker in MEWDS-eyes compared with the baseline, with a significant decrease of 9% at 3 months. Within the lesion, INL thickness was 7.9% increased at baseline and decreased significantly over the follow-up of 12 months. BCVA was decreased at baseline (0.2 +/- 0.18logMAR) and at the 3 months but after 12 months had increased to 0.01 +/- 0.04 logMAR. Conclusion: MEWDS shows the involvement of different retinal layers and characteristic changes over the disease course.