Primary Iga-Mediated Autoimmune Hemolytic Anemia In An Infant Successfully Treated With Rituximab
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY(2020)
摘要
Autoimmune hemolytic anemia (AIHA) is uncommon in the pediatric population and is often associated with an infectious etiology or postvaccination. Mostly, the child presents with a positive direct antiglobulin test. The diagnosis can be challenging, as in our case with an immunoglobulin A-mediated AIHA. In addition to supportive therapy, such as a red blood cell transfusion, steroids are the first choice of treatment. Rituximab, as second-line treatment, can be given in conjunction. We report the first case of immunoglobulin A-mediated AIHA treated with rituximab in the literature.
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关键词
IgA-mediated autoimmune hemolytic anemia, antiglobulin test, livedo reticularis, rituximab, vaccinations
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