Regulation of Adult Female Germline Stem Cells by Nutrient-responsive Signaling

•Systemic factors control dietary response of GSCs via acting on the GSC itself, GSC niche cells, and the adipose tissue surrounding the ovary.•The adipose tissue, a nutrient sensing organ, uses insulin/IGF signaling and amino acid response pathways to control GSC maintenance.•GSC intrinsic regulators, niche local signals, and adipocyte local signals are coordinated to control GSC response to nutrient inputs.