Mechanisms of resistance to mTOR inhibitors

Luigi Formisano,Fabiana Napolitano,Roberta Rosa,Valentina D’Amato,Alberto Servetto,Roberta Marciano,Pietro De Placido,Cataldo Bianco,Roberto Bianco

Critical Reviews in Oncology/Hematology（2020）

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摘要

•PI3K/AKT/mTOR pathway is disrupted in multiple tumor types.•Several class of mTOR inhibitors exist, with different mechanisms of resistance.•It is crucial to identify factors predictive/prognostic of response/resistance.•Predictive factors may help to select patients benefiting from a specific agent.•Novel and different mechanisms of resistance are still under investigation.

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关键词

mTOR inhibitors,Mechanisms of resistance,Predictive factors

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