Oxidized-ATP Attenuates Kidney Allograft Rejection By Inhibiting T-Cell, B-Cell, and Macrophage Activity.

Xiang Ding,Nancy A. Wilson,Robert Redfield,Sarah E. Panzer,Bret Verhoven,Shannon R. Reese,Weixiong Zhong,Lei Shi,William Burlingham,Loren Denlinger,Arjang Djamali

Kidney360（2020）

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摘要

Our findings suggest that oATP mitigates kidney allograft rejection by inhibiting T-cell, B-cell, and macrophage activity and indicate a potential role for the purinergic system and oATP in solid organ transplantation.

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关键词

Antibody mediated rejection,B cell,Basic Science,IL6,Kidney transplantation,Macrophages,P2X7R,Rejection,T cell,Transplantation,allograft,oATP,purinergic receptor

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