What is reproducibility? [version 1; peer review: 3 approved with reservations]

The debate on reproducibility in biomedicine will gain precision only if we agree what reproducibility means. Importantly, reproducibility should be distinguished from validity (“truth”). We propose the application of an equivalence trials framework to clarify the concept of reproducibility by changing the (narrow) equivalence zone around a zero difference by a zone of reproducibility around (a) previous finding(s).