TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation

Dear Editor, The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health (Ding and Schloss, 2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease, allergy, diabetes, obesity, and inflammatory bowel disease (IBD), which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models (Saleh and Elson, 2011).