Boron/Zinc Exchange For The Conjugate Arylation Of Unsaturated Meldrum'S Acid Derivatives
TETRAHEDRON(2020)
摘要
An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the beta-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as beta,beta-disubstituted carboxylic acids and amides. (C) 2020 Elsevier Ltd. All rights reserved.
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关键词
Meldrum's acid, Organozinc reagents, Arylation, Boronic acids
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