Isolated diaphragmatic metastasis originating from early endometrial cancer

Metastatic diaphragm tumors are rare. We herein describe an extremely rare case of isolated diaphragmatic metastasis from an endometrial cancer. A 47-year-old asymptomatic woman, who had previously undergone surgical resection for stage IA endometrial cancer with high uptake of fluorodeoxyglucose, presented with a diaphragmatic tumor. The resected diaphragmatic specimen revealed adenocarcinoma within the diaphragm, which was similar to the previous endometrial cancer. The tumor was eventually diagnosed as a diaphragmatic metastasis from endometrioid adenocarcinoma of uterus. Diaphragmatic metastasis should be considered in the differential diagnosis in patients with previous malignancies that show high fluorodeoxyglucose uptake, even in early-stage primary tumors.