Tunable pH-Sensitive 2-Carboxybenzyl Phosphoramidate Cleavable Linkers

Brian S. Backer,Cindy J. Choy,Austen L. Davis, Zachery S. Browne,Clifford E. Berkman

Tetrahedron Letters（2020）

引用 8|浏览4

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摘要

•The pKa of the benzoate in 2-carboxybenzyl phosphoramidates controlled hydrolysis.•The rate of amine-release was inversely correlated with Hammett sigma values.•The mechanism of hydrolysis proceeds through a transient cyclic acyl-phosphate.

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关键词

Cleavable Linker,Phosphoramidate,Hammet effects,Hydrolysis

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