Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern ChinaWOS

    HM Adnan Hameed
    HM Adnan Hameed
    Mahmudul Islam
    Mahmudul Islam
    Zhili Lu
    Zhili Lu
    Chiranjibi Chhotaray
    Chiranjibi Chhotaray
    Shuai Wang
    Shuai Wang
    Cuiting Fang
    Cuiting Fang
    Jianxiong Liu
    Jianxiong Liu
    Cited by: 0|Bibtex|11|

    Infection and Drug Resistance, pp. 217-227, 2020.

    Keywords:
    drug resistanceframeshift deletionmolecular diagnosisnovel mutationspyrazinamidaseview more (1+)

    Abstract:

    Our study revealed that PZA rate in MDR and pre-XDR TB was markedly higher in southern China. The concomitant evaluation of UFR, and provides more dependable genotypic results of PZA resistance. Fifty-seven novel mutations/indels in this study may play a vital role as diagnostic markers. The upstream region of and PZase regulation ar...More
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