Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern ChinaWOS
Infection and Drug Resistance, pp. 217-227, 2020.
Keywords:drug resistanceframeshift deletionmolecular diagnosisnovel mutationspyrazinamidaseview more (1+)
Our study revealed that PZA rate in MDR and pre-XDR TB was markedly higher in southern China. The concomitant evaluation of UFR, and provides more dependable genotypic results of PZA resistance. Fifty-seven novel mutations/indels in this study may play a vital role as diagnostic markers. The upstream region of and PZase regulation ar...More