Upregulation of microRNA-195 ameliorates calcific aortic valve disease by inhibiting VWF via suppression of the p38-MAPK signaling pathway

•The role of miR-195 in aortic valve calcification is explored.•miR-195 is downregulated yet VWF is upregulated in aortic valve calcification.•miR-195 targets VWF and negatively regulates its expression.•miR-195 inhibits aortic valve calcification by inhibiting VWF and p38-MAPK pathway.•This study provided a new direction for treatment of aortic valve calcification.