Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

•A comparison in DIAN by considering the 3 genes and Machine Learning.•Feature selection based on ANOVA followed by Principal Component Analysis (PCA).•SVM in a nested k-Fold CV resulted in accuracies of 72–74% using PiB PET features.•PSEN1 subgroups vs. NC provided accuracies of 80%, DIAN as an heterogeneous entity.