Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis

•A high sugar and fat diet affects multiple systems and organs.•Alcohol extracts of the G. lucidum fruit body can improve the microbiome-gut-liver axis.•Alcohol extracts of the G. lucidum fruit body can improve the microbiome-gut-brain axis.•Alcohol extracts of the G. lucidum fruit body can regulate the CNS and improve metabolic regulation.